CELLULAR AND FUNCTIONAL EVALUATION OF LDLR MISSENSE VARIANTS REPORTED IN HYPERCHOLESTEROLEMIC PATIENTS DEMONSTRATES THEIR HYPOMORPHIC IMPACTS ON TRAFFICKING AND LDL INTERNALIZATION

BackgroundFamilial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by increased LDL-cholesterol levels.About 85% of FH cases are caused by LDLR mutations encoding the low-density lipoprotein receptor (LDLR).LDLR is synthesized in the endoplasmic reticulum (ER) where it undergoes post-translational modifications and then tr

The multifaceted interplay of economic and political factors in the process of euro adoption suggests the opportunity to take a political economy perspective on this complex issue.In this sense, a number of key political-economy related issues can be distilled in relation to the process of euro adoption, which will structure the following analysis.

Estimates of paleodiversity patterns through time have relied on datasets that lump taxonomic occurrences from geographic areas of varying size per interval of time.In essence, such estimates assume that the species-area effect, whereby more species are recorded from larger geographic areas, is negligible for fossil data.We tested this assumption b

Abstract Energy storage technologies (ESTs) play an important role in integrated, decentralized renewable energy systems.However, the lack of public acceptance and awareness of ESTs can significantly delay or block the implementation of renewable energy projects.This study aims to identify the societal and legislative barriers to implementing ESTs

The current COVID-19 pandemic is motivating us to Loaf Pans elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility.We found that SARS-CoV-2 could increase the protein level of ACE2 in mice.Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2